Extracellular Cl− regulates human SO4 2−/anion exchanger SLC26A1 by altering pH sensitivity of anion transport
نویسندگان
چکیده
منابع مشابه
Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH.
SLC26A3, a Cl(-)/HCO(3)(-) exchanger, is highly expressed in intestinal epithelial cells, and its mutations cause congenital chloride diarrhea. This suggests that SLC26A3 plays a key role in NaCl absorption in the intestine. Electroneutral NaCl absorption in the intestine is mediated by functional coupling of the Na(+)/H(+) exchanger and Cl(-)/HCO(3)(-) exchanger. It is proposed that the coupli...
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Slc26a2 is a ubiquitously expressed SO4 transporter with high expression levels in cartilage and several epithelia. Mutations in SLC26A2 are associated with diastrophic dysplasia. The mechanism by which Slc26a2 transports SO4 and the ion gradients that mediate SO4 uptake are poorly understood. We report here that Slc26a2 functions as a SO4/2OH, SO4/2Cl and SO4/OH/Cl exchanger, depending on the ...
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An oxothiosquaramide was shown to bind to chloride through hydrogen bonding interactions in DMSO and found to exhibit pH switchable choride transport across phospholipid bilayers via an antiport transport mechanism.
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We report the molecular and functional characterization of murine Slc26a6, the putative apical chloride-formate exchanger of the proximal tubule. The Slc26a6 transcript is expressed in several tissues, including kidney. Alternative splicing of the second exon generates two distinct isoforms, denoted Slc26a6a and Slc26a6b, which differ in the inclusion of a 23-residue NH(2)-terminal extension. F...
متن کاملpH sensitivity of ammonium transport by Rhbg.
Rhbg is a membrane glycoprotein that is involved in NH(3)/NH(4)(+) transport. Several models have been proposed to describe Rhbg, including an electroneutral NH(4)(+)/H(+) exchanger, a uniporter, an NH(4)(+) channel, or even a gas channel. In this study, we characterized the pH sensitivity of Rhbg expressed in Xenopus oocytes. We used two-electrode voltage clamp and ion-selective microelectrode...
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ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2016
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-016-1823-8